Mitogen and Stress-Activated Kinases 1 and 2 Mediate Endothelial Dysfunction

Posted: 13th December 2021

Researchers from TICR describe a new pathway that could be important in the development of cardiovascular disease.

Inflammation promotes endothelial dysfunction, but the underlying mechanisms remain
poorly defined in vivo. Using translational vascular function testing in myocardial infarction patients,
a situation where inflammation is prevalent, and knock-out (KO) mouse models we demonstrate a
role for mitogen-activated-protein-kinases (MAPKs) in endothelial dysfunction… Read more

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