Professor Faisel Khan

Professor Faisel Khan, BSc (hons), PhD

Faisel Khan is Professor of Cardiovascular Science and Associate Dean International. He is a Clinical Scientist whose research programme focuses on the role of the endothelium in early development and progression of cardiovascular disease.

Professor Khan has over 30 years’ experience in clinical research and has been involved in many observational and intervention trials as well as trials of investigational medicinal products. He has expertise in vascular physiology and in the assessment of vascular function.

A key aspect of his research is to bridge basic science and clinical medicine by forming a better understand the underlying signalling pathways involved in development of cardiovascular disease.

He has published over 160 research papers in this area and has been the principal or co-applicant on successful grant applications totalling over £15 million. Professor Faisel Khan serves as a Council Member for the Royal Society of Medicine’s Vascular and Lipids Section and is a Member of the European Society of Vascular Medicine Scientific Committee. He is also the current National Delegate for UK for the International Union of Angiology.

Professor Faisel Khan is an accredited postgraduate degrees supervisor and has supervised 50 postgraduate students in this area of research.

Impact of Research

Translational research programme leading to better identification of early markers of cardiovascular disease risk and unravelling underlying pathways of disease that can be targeted for development of new treatments and direct patient impact.

A few of Professor Faisel Khan’s Publications

1.         Aizawa K, Gates PE, Mawson DM, Casanova F, Gooding KM, Hope SV, Goncalves I, Nilsson J, Khan F, Colhoun HM, Natali A, Palombo C, Shore AC. Type 2 diabetes exacerbates changes in blood pressure-independent arterial stiffness: cross-sectional and longitudinal evidence from the SUMMIT study. Journal of Applied Physiology 2023; (E-pub ahead of print).

2.          Peh ZH, Dihoum A, Hutton D, Arthur JSC, Rena G, Khan F, Lang CC, Mordi IR. Inflammation as a therapeutic target in heart failure with preserved ejection fraction. Frontiers in Cardiovascular Medicine. 2023 Jun 29;10:1125687. doi: 10.3389/fcvm.2023.1125687. PMID: 37456816; PMCID: PMC10339321.

3.          Genovese F, Gonçalves I, Nielsen SH, Karsdal MA, Edsfeldt A, Nilsson J, Shore AC, Natali A, Khan F, Shami A. Plasma levels of PRO-C3, a type III collagen synthesis marker, are associated with arterial stiffness and increased risk of cardiovascular death. Atherosclerosis.2024, 388: 6 p117420

4.          Shek N, Choy AM, Lang CC, Miller BE, Tal-Singer R, Bolton CE, Thomson NC, Chalmers JD, Bown MJ, Newby DE, Khan F, Huang JTJ. Accelerated elastin degradation by age-disease interaction: a common feature in age-related diseases. NPJ Aging. 2024 Feb 27;10(1):15. doi: 10.1038/s41514-024-00143-7. PMID: 38413600.

5.          Markwalder L, Gush R, Khan F, Murdoch CE, Krstajić N. In vivo laser speckle contrast imaging of microvascular blood perfusion using a chip-on-tip camera. iScience. 2024 Feb 1;27(3):109077. doi: 10.1016/j.isci.2024.109077. PMID: 38375226; PMCID: PMC10875563.